Predictors of dengue severity.
نویسنده
چکیده
Pone et al., in a study published in this Journal, have attempted to identify historical or observable signs or symptoms that reliably predict worsening of dengue disease in children.1 In so doing, they have coined a new term ‘‘serious dengue disease’’ and adopted a new clinical outcome metric, ‘‘treatment modality.’’ The ‘‘treatment modalities’’ chosen include administration of ‘‘amines, inotropes, colloids, mechanical ventilation, non-invasive ventilation, peritoneal dialysis or hemodialysis.’’ Lethargy, abdominal distension, pleural effusion, and hypoalbuminemia were the most reliable markers of serious dengue disease identified in 145 children hospitalized in Rio de Janeiro in 2007--2008, who had direct or indirect evidence of recent dengue infection. The authors are among those who would agree that a more accurate identification of dengue predictors would best be derived from large protocol-based prospective studies of physiologically characterized laboratory confirmed dengue illnesses. There is considerable historical precedent for this effort. Ever since the 1950s, when it was recognized that dengue viruses caused a severe and often fatal acute febrile disease of children, it has been the goal of researchers to describe the pathophysiology of dengue disease aiming to provide better treatment and to identify predictive early warning markers to improve triage.2,3 This was the motivation behind the creation of the case definitions, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), in wide use since their adoption by WHO in 1975, and the new case definitions introduced in 2009.4,5 In the 1960s,
منابع مشابه
Development of Dengue Infection Severity Score
Objectives. To develop a simple scoring system to predict dengue infection severity based on patient characteristics and routine clinical profiles. Methods. Retrospective data of children with dengue infection from 3 general hospitals in Thailand were reviewed. Dengue infection was categorized into 3 severity levels: dengue infection (DF), dengue hemorrhagic fever (DHF), and dengue shock syndro...
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BACKGROUND There is lack of reliable predictors of disease severity and mortality in dengue. The present study was carried out to identify these predictors during the 2015 outbreak in India. METHODS This prospective observational study included confirmed adult dengue patients hospitalized between August and November 2015 in a tertiary care centre in New Delhi, India. Appropriate statistical t...
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Dengue virus (DENV) infection is a mosquito born disease that is endemic in all WHO regions, except European region, and may present a broad range of severity. It may appear as an asymptomatic condition, dengue fever (DF), or life threatening forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), or the currently defined severe dengue. Currently there are means to diagno...
متن کاملDengue fever--predictors of disease severity and their influence on management.
Introduction The annual global figures for dengue fever (DF) and dengue haemorrhagic fever (DHF) are about 100 million and half a million respectively, and 90% of the patients are children <15 years [1]. Case fatality in Asia is 0.5 3.5% [2]. The first major epidemic in Sri Lanka was in 1989. The dengue pandemic in 1998 led to a resurgence of interest in its prevention and management. Clearly, ...
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عنوان ژورنال:
- Jornal de pediatria
دوره 92 5 شماره
صفحات -
تاریخ انتشار 2016